World's first baby born from 3-parent technique: watch video

The world's first child was born using a revolutionary technique that combines generating three parents, reports the Daily Mail.
Five months old Abrahim Hassan Jordanian parents, Ibtisam Shaban and Mahmoud Hassan, was treated by an American-based team in Mexico, using a controversial technique
- which has only been legally approved in the UK - which provides parents with rare genetic mutations that have healthy babies. The world's first child was born thanks to a controversial new technique employed by American researchers to include DNA from three parents of the embryo, said a report Tuesday.
Shaban carrying genes for Leigh syndrome, a rare genetic disorder characterized by degeneration of the central nervous system; brain, spinal cord and optic nerve. Although she is healthy, Shaban first two children died due to Leigh syndrome, so she sought help from New Hope Fertility Center in New York.
The doctors, led by John Zhang, designed a new "three-parent" technique.
The traditional way to do this is to use a method known as pronuclear transfer, which involves fertilizing both the mother's egg and a donor egg with the father's semen. When both egg begins dividing into early-stage embryos, scientists remove the nucleus. The core from the donor eggs discarded, and a maternal inserted in its stead. This is the technique that was legally approved in England in 2015.
But the couple denied this technique for religious reasons - they did not want a foetus should be discarded. Another "three parents" technique, known as spindle Nuclear Transfer, was used. The core was first removed from the mother's egg and inserted into a donor egg after removing its own nucleus. Only then was the resulting eggs fertilized with the father's semen.
No method has been approved in the US, Zhang went to Mexico instead, where he says "there are no rules." He states that he made the right choice. "Saving lives is the ethical thing to do," he says.
"This is a milestone technique. This proves for the first time that genetic information from three people could avoid the disease. We now know reconstitution of human eggs can produce a healthy baby. No other technique has been established," Zhang told DailMail.
The team will describe the results at the American Society for Reproductive Medicine scientific congress in Salt Lake City in October.
Zhang and his team are expected to describe their method at the American Society for Reproductive Medicine meeting in Salt Lake City, Utah, next month.

An abstract describing the research has been published in the journal Fertility and Sterility, but outside experts said much more remains to be understood about the research.

"As this technology is controversial and a world first, I think investigators should have submitted a manuscript for full peer review instead of announcing these results in this way," says Justin St John, professor and director of the Center for genetic diseases Monash University.

Trials began in the 1990s to create a baby by injecting mitochondrial DNA from a donor in the mother's egg and add sperm from her partner.

"Some of the babies went on to develop genetic diseases, and the technique was banned," said New Scientist report.

"The problem may have arisen from babies have mitochondria from two sources."

Another outside expert, David Clancy, associate professor at Lancaster University, recalled that trials in monkeys have shown that the mother's mitochondrial DNA can extend from low levels to significantly higher levels "that would allow disease again transferred, so we must expect that the possibility of people. "

For now, Zhang and his team said his mitochondria has been tested and "they found that less than 1 percent carry the mutation," the report said.

"Hopefully, this is too low to cause any problems, in general it is thought to take about 18 percent of the mitochondria to be affected before problems start."

In addition, he is a guy ensure that he could not pass down any inherited mitochondrial DNA.

"While we should be wary of this technique as new information and research accumulates, so let's hope this child grow up and have a long healthy life," said Clancy.

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